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The p300/CBP (CREB-binding protein) coactivator proteins are histone acetyltransferases that help regulate the transcription of many genes.Based on this information,these proteins are involved in


A) DNA acetylation.
B) chromatin remodeling.
C) recruitment of RNA pol II.
D) formation of the transcription initiation complex.

E) C) and D)
F) B) and D)

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The lactose analog isopropyl- β\beta -D-thio-galactoside (IPTG) is often used to regulate gene expression systems in bacteria.IPTG does not act as a substrate for β\beta -galactosidase,but can bind to,and inactivate,repressor.In this case,IPTG serves as a(n)


A) inducer.
B) repressor.
C) effector.
D) operon.

E) B) and C)
F) A) and D)

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Which of the following statements regarding the ubiquitin-proteosome pathway is false?


A) This pathway is used to regulate expression of a number of cell surface receptors.
B) When proteins are destroyed by the proteosome,the ubiquitin moiety is not destroyed,but rather cleaved off and reused.
C) Ubiquitin ligase adds ubiquitin residues to targeted proteins in a stepwise fashion.
D) Ubiquitination of a targeted protein requires only one molecule of ATP.

E) A) and B)
F) None of the above

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You are working to identify enhancer regions of a particular gene.You should look


A) immediately upstream of the promoter.
B) immediately downstream of the promoter.
C) primarily upstream of the promoter;distance from the promoter does not matter.
D) primarily downstream of the promoter;distance from the promoter does not matter.

E) B) and D)
F) A) and B)

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Small RNAs can regulate gene expression.One type,called micro RNA (miRNA) ,acts by binding directly to


A) mRNA to prevent translation.
B) tRNA to prevent transcription.
C) mRNA to prevent transcription.
D) tRNA to prevent translation.

E) All of the above
F) B) and C)

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